Diagnostic decision support vendor Isabel Healthcare grew out of a distinctly different culture in the U.K. After his three-year-old daughter Isabel nearly died from a missed diagnosis at a London hospital in 1999, Jason Maude didn't sue for malpractice. He joined with attending physician Dr. Joseph Britto to develop a system that could prevent similar errors.
The Isabel system offers a Web-based checklist to help clinicians process symptoms and test results to arrive at an accurate diagnosis, offering possibilities that are so uncommon that a physician might only see it a couple of times during a career. (Maude's daughter Isabel had necrotizing fasciitis, the same rare, flesh-eating bacterial disease that Dr. Atul Gawande famously described in his book, "Complications: A Surgeon's Notes on an Imperfect Science.")
Isabel, which has a database of more than 100,000 documents and "knowledge kernels," works as a standalone app or it can be integrated with an EHR to draw data directly from the patient's record.