Something else does: he's looking at the face of a woman who works for EdX, the MIT/Harvard consortium for open learning. The woman herself is sitting off to the side of the room, but her image is projected onto a teleprompter-like screen above one of the cameras filming Lander's lecture. She's the proxy for the 36,000 students registered to take the course online, people drawn by the chance to take basic biology from one of the world's most famous scientists, a leading researcher on the Human Genome Project.
Otherwise, he teaches the way he usually does. He interacts with the roughly 90 students in the room, sometimes digressing from his lecture notes to work through an interesting question a student raises. These digressions might get cut from the main lecture and turned into optional "shaggy dog" stories for the students online. He writes things on the room's sliding whiteboards. He calls up the occasional image on his laptop.
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Ironically, his in-person students cannot use computers during his class, to prevent them from falling prey to Facebook, chat sessions or even homework for other classes.
Introductory biology classes not being filmed for use as a massive open online course (MOOC) are taught in 55-minute sessions three days a week. Lander teaches his MOOC class from 7 p.m. until 9 p.m. two nights a week. Students get a free dinner beforehand outside the auditorium. Then he stays and records "bumpers," short video introductions to each class, to quizzes and problem sets and other components of the course.
Getting this course online requires immense effort for both MIT and EdX. On MIT's side, Lander tapped Michelle D. Mischke, a PhD in pharmacology who for the last 15 years has been technical instructor for the department of biology at MIT, meaning she develops problem sets and exams and works to support students day-to-day.
A rendering of the protein lysozome, with some of its amino acids highlighted. In the course, students can rotate it and zoom in or out.
Lander and Mischke first met in May 2012 to discuss developing a MOOC version of the course. "I said, 'this is an enormous undertaking, we need about three of me to even consider doing this,'" Mischke recalls. "He said, 'build the team.'"
To build out the courseware, she's hired a project manager, a curriculum development specialist and a programmer who is building things like problem sets that include three-dimensional models of proteins, which can be viewed from 360 degrees. She also has help from MIT biology graduate students.
For EdX, developing the course meant "double or triple our investment in any other course," said Rob Rubin, EdX's VP of engineering. It has a learning management system in place, but the needs of specific professors drive new features in it, and there's plenty of custom coding that needs to take place.
It was the first time a biology class had been taught on its platform, so EdX engineers had to build all the potential problem types that biology students would normally see on problem sets, to understand the economics of building the sets. Lander wanted to be able to go into the forums and take a good student answer to a basic question and "pin" it to the top of that discussion thread, so Rubin's team had to figure out how to build a pinning feature.
"It's a huge engineering and software development project to get our problems to work," admitted Mischke, who said the course's demands mean she spends probably another 40 hours a week on top of her normal job.