This white paper talks about Implementation of TB Systems in Botswana Using the VB.Net Platform. The first electronic TB system in Botswana was developed in 1995 to provide timely and accurate TB management information. Developed in Epi Info 6 (DOS), it became necessary to upgrade the application to a more current platform based on user and technical requirements. In 2000, an Isoniazid TB Preventive Therapy (IPT) programme was piloted. Based on the pilot evaluation, the programme was expanded nationwide, thus necessitating the need for an electronic system.