FreeHand, a rival to Adobe Illustrator, was a PostScript drawing program developed by Altsys and licensed to Aldus. Graphic artists and designers preferred Illustrator, while technical artists and mapmakers gravitated to FreeHand. Its interface was more discoverable than Illustrator's, which made it more accessible for semi-regular use. When Adobe bought Aldus, the program reverted to Altsys, which later sold it to Macromedia, and the eventual purchase of Macromedia by Adobe spelled the end of FreeHand development.
Even though, in some cases, some of this "lost" software is still sold, most of it is long gone -- sometimes the parent company went out of business, sometimes a competitor bought it and killed it (or bought it to kill it), or it becomes a victim of changing standards. Here's to those we miss.