Drew pleaded not guilty Monday. She posted $20,000 bail and is scheduled for trial later this month.
The Los Angeles indictment marks the first time that a social networking site user has faced federal charges related to accessing protected computers for harassment.
Prosecutors said Drew posed as a fictitious boy, Josh Evans, and feigned romantic interest in Meier before turning on her and saying "the world would be a better place" without the 13-year-old girl.
Meier hanged herself. She died the next day.
MySpace prohibits people from using fraudulent registration information; using accounts to obtain personal information about juvenile members; using the MySpace communication services to harass, abuse, or harm other members; and promoting false or misleading information.
If convicted, Drew faces up to five years imprisonment for the conspiracy count and up to five years for each of three counts charging that she accessed protected computers without authorization, according to a statement from the U.S. Attorney's Office in the Central District of California. She has also been the victim of cyberbullying since news of her alleged actions became public.
The case is in California because that's where MySpace's servers are located. Prosecutors consider the social networking site a victim in the case.