"The transformation of the PC to new form factors like the tablet is going to make some people uneasy because the PC has taken us a long ways," said Jobs, who spoke Tuesday at the D technology conference near Los Angeles.
"The PC is brilliant," said Jobs. "We like to talk about the post-PC era, but it's uncomfortable," he added.
Jobs' comments came a week after Apple surpassed Microsoft in market capitalization. Critics say Microsoft's reliance on its Windows cash cow has kept it from matching Apple's moves into hot new markets like tablet computing and mobile communications.
Jobs said tablets will represent an even bigger threat to PCs in the future as the software that powers them improves enough to facilitate advanced tasks like content creation and editing.
"These devices over time are going to grow to do new things," Jobs said.
Jobs also used his appearance at the conference to take another swipe at Adobe and its Flash online video technology.
"We don't think Flash makes a great product, so we're leaving it out," said Jobs, referring to Apple's decision not to support Flash on the iPhone or iPad.
"We're going to focus on technologies that are in ascendancy. If we succeed, people will buy them and if we don't they won't. And, so far, I have to say people seem to be liking the iPad. We sell like three iPads a second," Jobs said at the conference, in Rancho Palos Verdes, Calif.
Jobs' remarks come on the heels of statements he made last month, in which he claimed Flash is slow, unstable, and the number one reason why Macs crash.
Adobe, for its part, has criticized Apple for not using Flash, accusing the company of attempting to dominate the Internet.