The plan announced Thursday will allow voters to send e-mail, text messages or instant messages to candidates during 11 live events from September through December of this year.
The events will be held mostly on college campuses in the mtvU network of more than 750 U.S. colleges and universities linked with its 24-hour college channel. They will stream live on the Internet through MySpaceTV and MTV.com.
College journalists from mtvU's College Media Network are scheduled to participate.
The two companies said voters can increase their chances of getting into the audience by adding the official event profile on MySpace.com to their Top 8 friends list and being one of the first to show up when a new campus location is revealed.
MTV.com users who submit the most compelling online videos on how they're addressing election issues that impact their community will be flown to the events.
A moderator will choose the questions, while political experts and an MTV newsperson will provide support. The events will also feature real-time polls.
Democratic Senators Hillary Rodham Clinton, Chris Dodd, and Barack Obama, as well as former Sen. John Edwards and New Mexico Gov. Bill Richardson, have agreed to participate.
Republican participants include: Senators John McCain and Sam Brownback, former Massachusetts Gov. Mitt Romney, former New York City Mayor Rudolph Giuliani and U.S. Rep. Ron Paul.
Edwards will be the first to appear during the one-hour events. The debut will be streamed from New Hampshire on Sept. 27.